Markus Müschen, MD-PhD

Markus Müschen, MD-PhD

Company: Yale University

Job title: Arthur H. and Isabel Bunker Professor of Hematology
Director, Center of Molecular and Cellular Oncology


Targeted PI3K-hyperactivation in B-cell Malignancies 1:30 pm

• 25% of all cancers are driven by PI3K-activating lesions, but B-cell malignancies are exempt • The vast majority of newly formed B-cells express autoreactive antibodies and are removed through a mechanism termed “negative B-cell selection”, based on excessive activation of PI3K-signaling • We propose to leverage “negative B-cell selection” by pharmacological PI3K-hyperactivation to overcome…Read more

day: Day One

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